PF-4708671

Across CCLE and GDSC cell-line panels, response to PF-4708671 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible PF-4708671 response-associated pathways across cancer lineages are Regulation of type II interferon production, Positive regulation of triglyceride metabolic process, and Aromatic amino acid transport, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PF-4708671 response versus Regulation of type II interferon production shRNA pathway dependency in BLOOD_Leukemia (Pearson r = -0.89).

Shrna pathway dependency biomarkers of PF-4708671 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of type II interferon production →	-0.468	-0.540	.019	.042	3	4
SKIN	Positive regulation of triglyceride metabolic process →	-2.338	-0.502	<.001	.016	3	4
SKIN	Aromatic amino acid transport →	-1.261	-0.364	.007	.016	3	4
SKIN	Cerebral cortex neuron differentiation →	+0.326	+0.351	.016	.022	3	4
BLOOD_Leukemia	Lipid import into cell →	+2.326	+0.775	.006	.017	3	3
BLOOD_Leukemia	Regulation of mesenchymal stem cell proliferation →	+2.485	+0.775	.016	.017	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PF-4708671 response vs Regulation of type II interferon production — BLOOD_Leukemia

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