PF-00299804

Across CCLE and GDSC cell-line panels, response to PF-00299804 is significantly associated with the RNA expression of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible PF-00299804 response-associated genes across cancer lineages are CDADC1, GSTO1, and FTL, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PF-00299804 response versus CDADC1 RNA expression in LARGE_INTESTINE (Pearson r = -0.35).

Rna expression biomarkers of PF-00299804 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDADC1 →	-0.641	-0.464	.026	.037	3	9
PANCREAS	GSTO1 →	-0.922	-0.644	.001	.002	3	9
LUNG_NSCLC_LUAD	FTL →	-1.406	-0.688	.004	.010	3	9
KIDNEY	MACROH2A2 →	+2.404	+0.464	.037	.049	3	8
KIDNEY	TFB2M →	+0.774	+0.403	.006	.031	2	9
BREAST	TFE3 →	-1.018	-0.761	<.001	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PF-00299804 response vs CDADC1 — LARGE_INTESTINE

Explore this scatter interactively →