PD173074

Across CCLE and GDSC cell-line panels, response to PD173074 is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible PD173074 response-associated pathways across cancer lineages are Sarcomere organization, Protection from non-homologous end joining at telomere, and Lipid oxidation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PD173074 response versus Sarcomere organization protein-level pathway activity in LUNG_SCLC (Pearson r = -0.39).

Protein-level pathway activity biomarkers of PD173074 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Sarcomere organization →	-0.276	-0.660	.005	.002	3	8
STOMACH	Protection from non-homologous end joining at telomere →	+0.220	+0.945	.009	.034	3	7
BREAST	Lipid oxidation →	-0.138	-0.409	.009	.007	3	7
SOFT_TISSUE	Protein-lipid complex remodeling →	+1.143	+0.855	.013	.037	3	7
SOFT_TISSUE	Plasma lipoprotein particle remodeling →	+1.143	+0.855	.013	.037	3	7
PANCREAS	Regulation of muscle system process →	-0.215	-0.488	.040	.004	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PD173074 response vs Sarcomere organization — LUNG_SCLC

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