PD0325901

Across CCLE and GDSC cell-line panels, response to PD0325901 is significantly associated with the RNA expression of multiple genes, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible PD0325901 response-associated genes across cancer lineages are ZNF263, NPAS2, and STX5, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PD0325901 response versus ZNF263 RNA expression in OESOPHAGUS (Pearson r = -0.41).

Rna expression biomarkers of PD0325901 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF263 →	-0.618	-0.503	.009	.029	3	11
BREAST	NPAS2 →	+2.430	+1.138	<.001	<.001	3	10
URINARY_TRACT	STX5 →	-0.984	-1.132	.002	.018	3	9
URINARY_TRACT	MAGED2 →	-1.267	-1.370	.041	.049	2	10
BLOOD_Myeloma	IRAK2 →	+2.042	+1.384	.007	.009	2	10
SOFT_TISSUE	SLC20A1 →	+1.915	+0.828	.002	<.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PD0325901 response vs ZNF263 — OESOPHAGUS

Explore this scatter interactively →