PCI-34051

Across CCLE and GDSC cell-line panels, response to PCI-34051 is significantly associated with the protein abundance of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible PCI-34051 response-associated proteins across cancer lineages are RTN4, PCYT1A, and TMED7, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PCI-34051 response versus RTN4 protein abundance in OVARY (Pearson r = -0.48).

Protein abundance biomarkers of PCI-34051 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RTN4 →	-0.864	-0.475	.001	.004	3	8
LUNG_NSCLC_LUSC	PCYT1A →	-1.592	-0.342	.039	.026	3	7
OVARY	TMED7 →	-0.645	-0.589	.006	.003	3	7
OVARY	NCEH1 →	-1.661	-0.499	.015	.011	3	7
BONE	PLEC →	-1.956	-0.382	.013	.038	3	7
CNS	MAP1B →	-1.709	-0.698	<.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCI-34051 response vs RTN4 — OVARY

Explore this scatter interactively →