PARP_9495

Across CCLE and GDSC cell-line panels, response to PARP_9495 is significantly associated with the protein-level pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible PARP_9495 response-associated pathways across cancer lineages are Alpha-amino acid metabolic process, Protein localization to nucleus, and Nuclear polyadenylation-dependent rRNA catabolic process, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PARP_9495 response versus Alpha-amino acid metabolic process protein-level pathway activity in BREAST (Pearson r = -0.50).

Protein-level pathway activity biomarkers of PARP_9495 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Alpha-amino acid metabolic process →	-0.204	-0.774	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Protein localization to nucleus →	+0.167	+0.577	.009	.023	3	9
BREAST	Nuclear polyadenylation-dependent rRNA catabolic process →	+1.297	+0.684	.001	<.001	3	9
BREAST	TRAMP-dependent tRNA surveillance pathway →	+1.297	+0.684	.001	<.001	3	9
BREAST	Lipid catabolic process →	-0.225	-0.644	<.001	<.001	3	9
BREAST	Branched-chain amino acid metabolic process →	-0.460	-0.661	<.001	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP_9495 response vs Alpha-amino acid metabolic process — BREAST

Explore this scatter interactively →