PARP_9482

Across CCLE and GDSC cell-line panels, response to PARP_9482 is significantly associated with the mutation status of multiple genes, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible PARP_9482 response-associated genes across cancer lineages are TP53, FAM135B, and DNAH1, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, PARP_9482 response grouped by TP53 status in KIDNEY.

Mutation status biomarkers of PARP_9482 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TP53 →	-2.807	-0.452	.019	.039	3	4
OESOPHAGUS	FAM135B →	+2.321	+0.758	.010	.006	3	3
BREAST	DNAH1 →	+2.672	+0.767	.039	.023	3	3
URINARY_TRACT	KDM6A →	+2.321	+0.843	.047	.008	3	2
LUNG_NSCLC_LUSC	LRP2 →	+2.321	+0.686	.047	.011	2	3
CNS	RYR2 →	+2.584	+0.678	.004	.002	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP_9482 response by TP53 status — KIDNEY

Explore this box plot interactively →