PARP_0108

Across CCLE and GDSC cell-line panels, response to PARP_0108 is significantly associated with the total protein of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible PARP_0108 response-associated proteins across cancer lineages are alpha-Catenin, Rab25, and FRA1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PARP_0108 response versus alpha-Catenin total protein in LARGE_INTESTINE (Pearson r = -0.58).

Total protein biomarkers of PARP_0108 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	alpha-Catenin →	-0.622	-1.262	.003	<.001	3	7
BREAST	Rab25 →	-1.125	-0.711	<.001	.019	3	7
OVARY	FRA1 →	+1.208	+1.274	.002	<.001	3	7
SOFT_TISSUE	FOXO3a_pS318_S321 →	-0.384	-1.155	.016	.006	3	6
PANCREAS	eIF4G →	+0.840	+0.925	.003	.003	3	6
OVARY	c-Jun_pS73 →	+0.614	+0.759	.016	.028	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP_0108 response vs alpha-Catenin — LARGE_INTESTINE

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