PAK_5339

Across CCLE and GDSC cell-line panels, response to PAK_5339 is significantly associated with the pathway activity of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible PAK_5339 response-associated pathways across cancer lineages are Vesicle transport along actin filament, Negative regulation of neutrophil migration, and Mastication, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, PAK_5339 response versus Vesicle transport along actin filament pathway activity in STOMACH (Pearson r = -0.54).

Pathway activity biomarkers of PAK_5339 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Vesicle transport along actin filament →	-0.155	-0.268	.044	.029	3	8
STOMACH	Negative regulation of neutrophil migration →	-1.902	-0.472	.003	.001	3	8
OVARY	Mastication →	+0.141	+0.455	.002	.012	3	7
OVARY	Learned vocalization behavior →	+0.141	+0.455	.002	.012	3	7
LARGE_INTESTINE	Establishment of monopolar cell polarity →	+0.101	+0.524	.003	.002	2	8
OVARY	Negative regulation of epithelial cell apoptotic process →	-0.137	-0.610	.026	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAK_5339 response vs Vesicle transport along actin filament — STOMACH

Explore this scatter interactively →