P22077

Across CCLE and GDSC cell-line panels, response to P22077 is significantly associated with the RNA expression of multiple genes, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible P22077 response-associated genes across cancer lineages are MVP, KATNIP, and HRCT1, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, P22077 response versus MVP RNA expression in SOFT_TISSUE (Pearson r = -0.70).

Rna expression biomarkers of P22077 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MVP →	-3.195	-1.112	.008	.003	3	10
BLOOD_Myeloma	KATNIP →	-0.810	-0.498	.008	.003	3	10
BONE	HRCT1 →	-2.226	-0.475	.036	.012	3	10
BLOOD_Lymphoma	TRIM56 →	-0.457	-0.580	.017	<.001	3	9
URINARY_TRACT	CPEB2 →	-1.299	-0.933	.005	<.001	3	9
BLOOD_Leukemia	NBR1 →	-0.848	-0.529	.004	.007	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P22077 response vs MVP — SOFT_TISSUE

Explore this scatter interactively →