P22077

Across CCLE and GDSC cell-line panels, response to P22077 is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible P22077 response-associated proteins across cancer lineages are PKC-a_pS657, FASN, and 4E-BP1_pS65, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, P22077 response versus PKC-a_pS657 total protein in BONE (Pearson r = -0.41).

Total protein biomarkers of P22077 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PKC-a_pS657 →	-1.173	-0.536	.039	.018	3	7
OVARY	FASN →	+0.598	+0.592	.020	.011	3	7
CNS	4E-BP1_pS65 →	+0.578	+0.668	.005	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Bcl-xL →	-0.865	-0.474	.003	.037	3	6
BONE	TAZ →	-0.646	-0.857	<.001	.003	3	5
LUNG_NSCLC_LUSC	Dvl3 →	-0.770	-0.556	.001	.030	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P22077 response vs PKC-a_pS657 — BONE

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