P22077

Across CCLE and GDSC cell-line panels, response to P22077 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible P22077 response-associated pathways across cancer lineages are Ossification, Positive regulation of stress-activated protein kinase signaling cascade, and Negative regulation of fat cell differentiation, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, P22077 response versus Ossification shRNA pathway dependency in BLOOD_Lymphoma (Pearson r = -0.84).

Shrna pathway dependency biomarkers of P22077 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Ossification →	-0.167	-0.791	.018	.030	3	7
LARGE_INTESTINE	Positive regulation of stress-activated protein kinase signaling cascade →	+1.197	+0.570	.002	.036	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of fat cell differentiation →	+0.220	+0.652	.003	.009	3	7
SOFT_TISSUE	Positive regulation of neutrophil migration →	-1.585	-0.788	.011	.024	3	7
LUNG_SCLC	Phosphate ion transport →	+1.451	+0.989	.005	.005	3	7
SKIN	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway →	+0.186	+0.712	.011	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P22077 response vs Ossification — BLOOD_Lymphoma

Explore this scatter interactively →