Oxaliplatin

Across CCLE and GDSC cell-line panels, response to Oxaliplatin is significantly associated with the pathway activity of multiple pathways, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible Oxaliplatin response-associated pathways across cancer lineages are Proteinogenic amino acid metabolic process, Purine ribonucleoside monophosphate biosynthetic process, and Endosomal transport, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Oxaliplatin response versus Proteinogenic amino acid metabolic process pathway activity in BLOOD_Myeloma (Pearson r = 0.71).

Pathway activity biomarkers of Oxaliplatin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Proteinogenic amino acid metabolic process →	+0.109	+1.280	.010	.007	3	10
PANCREAS	Purine ribonucleoside monophosphate biosynthetic process →	+0.165	+0.819	.002	.022	3	10
BLOOD_Myeloma	Endosomal transport →	-0.050	-1.057	.001	.039	2	10
PANCREAS	Endoplasmic reticulum unfolded protein response →	-0.107	-0.509	.008	.019	3	9
STOMACH	Protein targeting to lysosome involved in chaperone-mediated autophagy →	-0.213	-0.760	<.001	.001	3	9
STOMACH	Negative regulation of autophagy →	-0.093	-0.648	<.001	.004	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Oxaliplatin response vs Proteinogenic amino acid metabolic process — BLOOD_Myeloma

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