Omipalisib

Across CCLE and GDSC cell-line panels, response to Omipalisib is significantly associated with the protein-level pathway activity of multiple pathways, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible Omipalisib response-associated pathways across cancer lineages are Kidney development, Response to iron ion, and Renal system development, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Omipalisib response versus Kidney development protein-level pathway activity in OESOPHAGUS (Pearson r = -0.44).

Protein-level pathway activity biomarkers of Omipalisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Kidney development →	-0.220	-0.852	.004	.011	3	7
OESOPHAGUS	Response to iron ion →	-0.379	-0.622	.047	.036	3	7
OESOPHAGUS	Renal system development →	-0.211	-0.904	.006	.009	3	7
PANCREAS	Positive regulation of mitotic cell cycle phase transition →	+0.981	+0.690	.005	.030	3	7
UPPER_AERODIGESTIVE_TRACT	Epithelium migration →	+0.925	+0.643	.008	.002	3	6
BONE	Protein hydroxylation →	-0.235	-1.004	.004	.017	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Omipalisib response vs Kidney development — OESOPHAGUS

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