Olaparib

Across CCLE and GDSC cell-line panels, response to Olaparib is significantly associated with the protein-level pathway activity of multiple pathways, with CNS cell lines showing a particularly strong set of associations.

The most reproducible Olaparib response-associated pathways across cancer lineages are Cellular response to prostaglandin E stimulus, Negative regulation of protein localization to plasma membrane, and Phospholipase C-activating G protein-coupled receptor signaling pathway, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Olaparib response versus Cellular response to prostaglandin E stimulus protein-level pathway activity in CNS (Pearson r = -0.43).

Protein-level pathway activity biomarkers of Olaparib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Cellular response to prostaglandin E stimulus →	-0.248	-0.455	.012	.010	3	10
LARGE_INTESTINE	Negative regulation of protein localization to plasma membrane →	-0.198	-0.448	<.001	.003	3	9
URINARY_TRACT	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-1.226	-0.589	.044	.016	3	9
BLOOD_Lymphoma	Neuron projection extension →	-0.510	-0.257	<.001	.036	3	9
BONE	Positive regulation of protein localization to chromatin →	+0.923	+0.966	.017	.001	3	9
BONE	Regulation of exocytosis →	-0.207	-0.728	<.001	<.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Olaparib response vs Cellular response to prostaglandin E stimulus — CNS

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