OTX015

Across CCLE and GDSC cell-line panels, response to OTX015 is significantly associated with the protein-level pathway activity of multiple pathways, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible OTX015 response-associated pathways across cancer lineages are Regulation of postsynapse assembly, Malate-aspartate shuttle, and Podosome assembly, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, OTX015 response versus Regulation of postsynapse assembly protein-level pathway activity in URINARY_TRACT (Pearson r = -0.58).

Protein-level pathway activity biomarkers of OTX015 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of postsynapse assembly →	-0.213	-0.706	.040	.025	3	7
CNS	Malate-aspartate shuttle →	-0.090	-0.517	.027	.005	3	7
OESOPHAGUS	Podosome assembly →	-1.021	-0.775	.002	.001	3	7
LUNG_NSCLC_LUAD	Poly(A)-dependent snoRNA 3'-end processing →	+0.802	+0.545	.023	.029	3	7
OESOPHAGUS	siRNA processing →	-1.286	-0.982	<.001	.001	3	6
CNS	U1 snRNA 3'-end processing →	+1.060	+0.827	.009	.002	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OTX015 response vs Regulation of postsynapse assembly — URINARY_TRACT

Explore this scatter interactively →