OSU-03012

Across CCLE and GDSC cell-line panels, response to OSU-03012 is significantly associated with the total protein of multiple proteins, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible OSU-03012 response-associated proteins across cancer lineages are SF2, AMPK_alpha, and Snail, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, OSU-03012 response versus SF2 total protein in SKIN (Pearson r = 0.31).

Total protein biomarkers of OSU-03012 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SF2 →	+0.336	+0.607	.027	.020	3	6
BLOOD_Lymphoma	AMPK_alpha →	-0.521	-0.511	.001	.007	3	5
LARGE_INTESTINE	Snail →	-0.873	-1.137	.010	.008	3	5
OVARY	HER3 →	-0.968	-0.748	.003	.001	3	5
LIVER	Ku80 →	+0.976	+0.530	.019	.019	3	5
SKIN	YAP →	-0.526	-0.866	.008	.002	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSU-03012 response vs SF2 — SKIN

Explore this scatter interactively →