OSU-03012

Across CCLE and GDSC cell-line panels, response to OSU-03012 is significantly associated with the protein-level pathway activity of multiple pathways, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible OSU-03012 response-associated pathways across cancer lineages are RNA 3'-end processing, tRNA surveillance, and RNA export from nucleus, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, OSU-03012 response versus RNA 3'-end processing protein-level pathway activity in LARGE_INTESTINE (Pearson r = 0.34).

Protein-level pathway activity biomarkers of OSU-03012 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNA 3'-end processing →	+0.141	+0.847	.046	.015	3	11
LIVER	tRNA surveillance →	+2.013	+0.697	.036	.004	3	11
STOMACH	RNA export from nucleus →	+0.209	+1.124	.039	.003	3	11
URINARY_TRACT	Nuclear mRNA surveillance →	+1.156	+0.988	.039	.039	3	10
LIVER	Nuclear polyadenylation-dependent rRNA catabolic process →	+1.915	+0.342	.037	.017	2	10
LIVER	TRAMP-dependent tRNA surveillance pathway →	+1.915	+0.342	.037	.017	2	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSU-03012 response vs RNA 3'-end processing — LARGE_INTESTINE

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