OF-1

Across CCLE and GDSC cell-line panels, response to OF-1 is significantly associated with the mutation status of multiple genes, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible OF-1 response-associated genes across cancer lineages are DNAH11, VPS13D, and CSMD3, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, OF-1 response grouped by DNAH11 status in OESOPHAGUS.

Mutation status biomarkers of OF-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNAH11 →	+2.491	+0.426	.049	.023	3	4
BLOOD_Leukemia	VPS13D →	+3.169	+0.216	.010	.044	3	4
STOMACH	CSMD3 →	+2.544	+0.433	.029	.031	3	3
LUNG_NSCLC_LUAD	DNAH9 →	+2.321	+0.489	.011	.002	3	2
BREAST	HYDIN →	+2.649	+0.531	.046	.029	3	2
SKIN	CENPF →	+2.748	+0.375	.042	.022	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OF-1 response by DNAH11 status — OESOPHAGUS

Explore this box plot interactively →