OF-1

Across CCLE and GDSC cell-line panels, response to OF-1 is significantly associated with the pathway activity of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible OF-1 response-associated pathways across cancer lineages are Regulation of plasminogen activation, Pyrimidine-containing compound transmembrane transport, and Purine nucleobase transport, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, OF-1 response versus Regulation of plasminogen activation pathway activity in LIVER (Pearson r = -0.65).

Pathway activity biomarkers of OF-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of plasminogen activation →	-0.374	-1.250	.003	.014	3	9
LIVER	Pyrimidine-containing compound transmembrane transport →	+0.225	+1.425	.042	.001	3	9
LARGE_INTESTINE	Purine nucleobase transport →	+0.106	+0.395	.006	.018	3	9
URINARY_TRACT	Positive regulation of extracellular matrix organization →	-0.221	-0.507	.014	.007	3	8
BREAST	Regulation of cell-substrate adhesion →	-0.076	-0.631	.005	.001	3	8
SOFT_TISSUE	Positive regulation of cell-substrate adhesion →	-0.108	-0.554	.013	.012	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OF-1 response vs Regulation of plasminogen activation — LIVER

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