Nelarabine

Across CCLE and GDSC cell-line panels, response to Nelarabine is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Nelarabine response-associated proteins across cancer lineages are Transglutaminase, IGFBP2, and VEGFR2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Nelarabine response versus Transglutaminase total protein in OVARY (Pearson r = -0.52).

Total protein biomarkers of Nelarabine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Transglutaminase →	-0.988	-0.490	.042	.008	3	8
BONE	IGFBP2 →	+1.962	+0.422	.007	.033	3	7
BLOOD_Lymphoma	VEGFR2 →	-1.386	-0.291	.004	.013	3	6
OVARY	Bcl-xL →	-0.790	-0.378	.003	.003	3	6
OVARY	C-Raf(BD610151) →	+1.423	+0.468	.001	.006	3	6
BLOOD_Leukemia	p62 Lck ligand →	-0.962	-0.691	<.001	.004	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Nelarabine response vs Transglutaminase — OVARY

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