NVP-TAE684

Across CCLE and GDSC cell-line panels, response to NVP-TAE684 is significantly associated with the pathway activity of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible NVP-TAE684 response-associated pathways across cancer lineages are Regulation of myeloid dendritic cell cytokine production, Positive regulation of myeloid dendritic cell cytokine production, and Embryonic cranial skeleton morphogenesis, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, NVP-TAE684 response versus Regulation of myeloid dendritic cell cytokine production pathway activity in SKIN (Pearson r = 0.73).

Pathway activity biomarkers of NVP-TAE684 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of myeloid dendritic cell cytokine production →	+0.116	+0.575	.009	.025	3	6
SKIN	Positive regulation of myeloid dendritic cell cytokine production →	+0.116	+0.575	.009	.025	3	6
CNS	Embryonic cranial skeleton morphogenesis →	+0.113	+0.828	.008	.008	3	5
SOFT_TISSUE	Regulation of protein kinase C activity →	+1.612	+0.144	<.001	.005	3	5
SOFT_TISSUE	Positive regulation of protein kinase C activity →	+1.612	+0.144	<.001	.005	3	5
BREAST	Regulation of astrocyte differentiation →	+0.339	+0.903	.005	.016	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NVP-TAE684 response vs Regulation of myeloid dendritic cell cytokine production — SKIN

Explore this scatter interactively →