NU7441

Across CCLE and GDSC cell-line panels, response to NU7441 is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible NU7441 response-associated proteins across cancer lineages are IGFBP2, VEGFR2, and FRA1, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, NU7441 response versus IGFBP2 total protein in BONE (Pearson r = 0.78).

Total protein biomarkers of NU7441 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IGFBP2 →	+2.584	+0.334	.020	.008	3	7
BLOOD_Lymphoma	VEGFR2 →	-1.533	-0.480	<.001	<.001	3	6
SOFT_TISSUE	FRA1 →	-1.242	-0.551	.003	.038	3	5
STOMACH	XBP1 →	+0.374	+0.773	.004	.001	3	5
BONE	HER2_pY1248 →	-0.555	-0.352	.007	.005	3	5
UPPER_AERODIGESTIVE_TRACT	HER3 →	-0.295	-0.569	.018	.006	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NU7441 response vs IGFBP2 — BONE

Explore this scatter interactively →