NU7441

Across CCLE and GDSC cell-line panels, response to NU7441 is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible NU7441 response-associated proteins across cancer lineages are BAD, BCL2L1, and STX7, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, NU7441 response versus BAD protein abundance in LUNG_SCLC (Pearson r = -0.50).

Protein abundance biomarkers of NU7441 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BAD →	-1.309	-0.930	<.001	<.001	3	9
BREAST	BCL2L1 →	-0.923	-0.593	.001	.004	3	9
URINARY_TRACT	STX7 →	-0.730	-0.788	.035	.006	3	8
SOFT_TISSUE	B2M →	-2.108	-0.586	<.001	.003	3	8
PANCREAS	DDX20 →	+0.927	+0.973	.002	<.001	3	8
LUNG_SCLC	RPL7 →	+0.601	+0.559	.004	.009	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NU7441 response vs BAD — LUNG_SCLC

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