NSC-87877

Across CCLE and GDSC cell-line panels, response to NSC-87877 is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible NSC-87877 response-associated proteins across cancer lineages are ARL6IP5, OGDHL, and RPL23A, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, NSC-87877 response versus ARL6IP5 protein abundance in BONE (Pearson r = -0.43).

Protein abundance biomarkers of NSC-87877 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARL6IP5 →	-1.112	-0.516	.004	.007	3	10
LUNG_SCLC	OGDHL →	-0.919	-0.224	.006	.023	2	10
OVARY	RPL23A →	+0.468	+0.484	.014	.017	3	9
BONE	RUVBL1 →	+0.840	+0.569	<.001	.002	3	9
BONE	HIBADH →	-0.943	-0.398	.007	.044	3	9
SOFT_TISSUE	NACA →	+1.151	+0.527	<.001	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSC-87877 response vs ARL6IP5 — BONE

Explore this scatter interactively →