NPK76-II-72-1

Across CCLE and GDSC cell-line panels, response to NPK76-II-72-1 is significantly associated with the shRNA dependency of multiple gene dependencies, with BONE cell lines showing a particularly strong set of associations.

The most reproducible NPK76-II-72-1 response-associated gene dependencies across cancer lineages are FIGNL2, CHRNB3, and FES, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, NPK76-II-72-1 response versus FIGNL2 shRNA dependency in BONE (Pearson r = 0.77).

Shrna dependency biomarkers of NPK76-II-72-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FIGNL2 →	+0.276	+1.274	.035	.033	3	7
STOMACH	CHRNB3 →	+0.196	+0.907	.001	.005	3	7
LARGE_INTESTINE	FES →	-0.191	-0.864	.001	.002	3	7
SOFT_TISSUE	DPH1 →	+0.375	+1.014	.048	.003	2	8
CNS	CDH24 →	+0.161	+0.650	.043	.009	3	7
BLOOD_Lymphoma	CYP46A1 →	+0.436	+0.999	.016	.008	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPK76-II-72-1 response vs FIGNL2 — BONE

Explore this scatter interactively →