N30652-18-1

Across CCLE and GDSC cell-line panels, response to N30652-18-1 is significantly associated with the protein abundance of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible N30652-18-1 response-associated proteins across cancer lineages are CBFB, ABHD12, and RPL35, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N30652-18-1 response versus CBFB protein abundance in STOMACH (Pearson r = 0.42).

Protein abundance biomarkers of N30652-18-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CBFB →	+0.909	+0.415	.009	.018	3	11
STOMACH	ABHD12 →	-1.307	-0.518	.004	.021	3	10
BREAST	RPL35 →	+0.711	+0.534	<.001	.002	3	10
LARGE_INTESTINE	BCL2L1 →	-1.267	-0.508	.006	.008	3	10
STOMACH	RPS8 →	+1.353	+0.917	.003	<.001	3	9
STOMACH	RPL5 →	+0.534	+0.492	.010	.004	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N30652-18-1 response vs CBFB — STOMACH

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