N30652-18-1

Across CCLE and GDSC cell-line panels, response to N30652-18-1 is significantly associated with the shRNA pathway dependency of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible N30652-18-1 response-associated pathways across cancer lineages are Positive regulation of interleukin-6 production, Negative regulation of receptor-mediated endocytosis, and CD4-positive, alpha-beta T cell activation, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N30652-18-1 response versus Positive regulation of interleukin-6 production shRNA pathway dependency in BREAST (Pearson r = 0.30).

Shrna pathway dependency biomarkers of N30652-18-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of interleukin-6 production →	+0.172	+0.309	.003	.040	3	8
BLOOD_Lymphoma	Negative regulation of receptor-mediated endocytosis →	-2.115	-0.550	.024	.045	2	8
CNS	CD4-positive, alpha-beta T cell activation →	-0.378	-0.375	.008	.026	3	7
BLOOD_Myeloma	Rap protein signal transduction →	-2.029	-0.683	<.001	.006	3	6
LUNG_NSCLC_LUSC	Cardiolipin metabolic process →	+1.865	+0.180	<.001	<.001	3	6
LARGE_INTESTINE	Natural killer cell activation involved in immune response →	+0.919	+0.334	.015	.027	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N30652-18-1 response vs Positive regulation of interleukin-6 production — BREAST

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