N29087-69-1

Across CCLE and GDSC cell-line panels, response to N29087-69-1 is significantly associated with the shRNA pathway dependency of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible N29087-69-1 response-associated pathways across cancer lineages are Secondary alcohol metabolic process, Amino-acid betaine catabolic process, and Pericardium morphogenesis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N29087-69-1 response versus Secondary alcohol metabolic process shRNA pathway dependency in SOFT_TISSUE (Pearson r = 0.63).

Shrna pathway dependency biomarkers of N29087-69-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Secondary alcohol metabolic process →	+1.435	+0.337	.006	.018	3	7
BLOOD_Lymphoma	Amino-acid betaine catabolic process →	-2.170	-0.745	.006	.028	3	7
BONE	Pericardium morphogenesis →	-1.438	-0.633	<.001	.007	3	7
SKIN	Inner cell mass cell differentiation →	-0.975	-0.301	.003	.015	3	7
BLOOD_Leukemia	Oligopeptide transport →	+1.722	+0.277	<.001	.049	3	6
PANCREAS	Metanephric distal tubule development →	-1.240	-0.770	.018	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N29087-69-1 response vs Secondary alcohol metabolic process — SOFT_TISSUE

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