N27922-53-1

Across CCLE and GDSC cell-line panels, response to N27922-53-1 is significantly associated with the total protein of multiple proteins, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible N27922-53-1 response-associated proteins across cancer lineages are Annexin_VII, PDCD4, and JNK2, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N27922-53-1 response versus Annexin_VII total protein in BLOOD_Myeloma (Pearson r = -0.57).

Total protein biomarkers of N27922-53-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Annexin_VII →	-0.611	-0.554	.041	.046	2	7
BONE	PDCD4 →	+1.328	+0.327	.017	.029	3	6
UPPER_AERODIGESTIVE_TRACT	JNK2 →	-0.241	-0.266	.029	.046	3	5
STOMACH	SF2 →	+0.326	+0.428	<.001	.005	3	4
LUNG_SCLC	p62 Lck ligand →	-1.553	-0.566	.006	.005	3	4
LUNG_NSCLC_LUAD	Fibronectin →	-1.396	-0.422	.005	.009	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N27922-53-1 response vs Annexin_VII — BLOOD_Myeloma

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