N25720-51-A1

Across CCLE and GDSC cell-line panels, response to N25720-51-A1 is significantly associated with the shRNA dependency of multiple gene dependencies, with CNS cell lines showing a particularly strong set of associations.

The most reproducible N25720-51-A1 response-associated gene dependencies across cancer lineages are TYK2, HTATSF1, and INTS6, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N25720-51-A1 response versus TYK2 shRNA dependency in CNS (Pearson r = 0.55).

Shrna dependency biomarkers of N25720-51-A1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TYK2 →	+0.244	+0.657	.018	.010	3	8
CNS	HTATSF1 →	+0.447	+0.532	.014	.032	3	7
LUNG_SCLC	INTS6 →	-0.322	-1.139	.015	.001	3	7
BLOOD_Leukemia	DMPK →	-0.232	-0.895	<.001	.002	3	7
LUNG_NSCLC_LUAD	NKX6-3 →	-0.147	-0.558	.015	.021	3	6
LUNG_NSCLC_LUAD	HLA-H →	-0.260	-0.794	.002	<.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N25720-51-A1 response vs TYK2 — CNS

Explore this scatter interactively →