N24798-49-A1

Across CCLE and GDSC cell-line panels, response to N24798-49-A1 is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible N24798-49-A1 response-associated gene dependencies across cancer lineages are TBR1, ZNF574, and BCL9, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N24798-49-A1 response versus TBR1 shRNA dependency in BLOOD_Lymphoma (Pearson r = -0.70).

Shrna dependency biomarkers of N24798-49-A1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TBR1 →	-0.280	-0.379	.007	.008	3	7
PANCREAS	ZNF574 →	-0.290	-0.500	<.001	.003	3	7
URINARY_TRACT	BCL9 →	+0.353	+0.543	.022	.019	3	7
PANCREAS	RNF2 →	+0.117	+0.257	.028	.036	3	7
PANCREAS	CABP4 →	+0.180	+0.289	.046	.038	3	7
LUNG_SCLC	USP16 →	+0.164	+0.299	.019	.035	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N24798-49-A1 response vs TBR1 — BLOOD_Lymphoma

Explore this scatter interactively →