N24798-49-A1

Across CCLE and GDSC cell-line panels, response to N24798-49-A1 is significantly associated with the protein-level pathway activity of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible N24798-49-A1 response-associated pathways across cancer lineages are Regulation of plasma membrane organization, Regulation of fatty acid oxidation, and 'de novo' IMP biosynthetic process, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N24798-49-A1 response versus Regulation of plasma membrane organization protein-level pathway activity in LIVER (Pearson r = -0.50).

Protein-level pathway activity biomarkers of N24798-49-A1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of plasma membrane organization →	-0.302	-0.182	.020	.011	3	10
LIVER	Regulation of fatty acid oxidation →	-0.713	-0.174	.017	.016	3	10
CNS	'de novo' IMP biosynthetic process →	+0.407	+0.209	.004	<.001	3	10
PANCREAS	Histone mRNA metabolic process →	+0.163	+0.252	.016	.011	2	11
SOFT_TISSUE	Positive regulation of mRNA processing →	+0.262	+0.241	<.001	.001	3	10
PANCREAS	U4 snRNA 3'-end processing →	+1.259	+0.318	.007	.003	3	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N24798-49-A1 response vs Regulation of plasma membrane organization — LIVER

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