N23918-95-7

Across CCLE and GDSC cell-line panels, response to N23918-95-7 is significantly associated with the shRNA pathway dependency of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible N23918-95-7 response-associated pathways across cancer lineages are Response to insulin-like growth factor stimulus, Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, and Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, N23918-95-7 response versus Response to insulin-like growth factor stimulus shRNA pathway dependency in SKIN (Pearson r = 0.56).

Shrna pathway dependency biomarkers of N23918-95-7 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Response to insulin-like growth factor stimulus →	+1.202	+0.576	.026	.002	3	7
LIVER	Regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	-2.066	-0.523	.001	.001	3	7
LUNG_NSCLC_LUAD	Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis →	-1.094	-0.322	.002	.004	3	7
URINARY_TRACT	Metanephric tubule morphogenesis →	-1.464	-0.386	.029	.014	3	6
URINARY_TRACT	Metanephric nephron tubule morphogenesis →	-1.464	-0.386	.029	.014	3	6
SOFT_TISSUE	Embryonic skeletal limb joint morphogenesis →	-1.933	-0.270	.007	.039	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

N23918-95-7 response vs Response to insulin-like growth factor stimulus — SKIN

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