Mycophenolic acid

Across CCLE and GDSC cell-line panels, response to Mycophenolic acid is significantly associated with the shRNA dependency of multiple gene dependencies, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Mycophenolic acid response-associated gene dependencies across cancer lineages are GJB3, UBE2G2, and PAFAH1B2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Mycophenolic acid response versus GJB3 shRNA dependency in LARGE_INTESTINE (Pearson r = -0.45).

Shrna dependency biomarkers of Mycophenolic acid response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GJB3 →	-0.262	-0.549	.002	.004	3	8
CNS	UBE2G2 →	-0.164	-0.957	.001	<.001	3	7
LARGE_INTESTINE	PAFAH1B2 →	+0.198	+0.534	.007	.004	3	7
BREAST	RAB35 →	+0.239	+0.674	.013	.004	3	6
BREAST	RER1 →	-0.417	-1.223	<.001	<.001	3	6
LARGE_INTESTINE	CSNK1A1L →	+0.174	+0.484	.009	.039	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mycophenolic acid response vs GJB3 — LARGE_INTESTINE

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