Mycophenolic acid

Across CCLE and GDSC cell-line panels, response to Mycophenolic acid is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Mycophenolic acid response-associated genes across cancer lineages are RIMS2, MYO15A, and PCDHGA5, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Mycophenolic acid response grouped by RIMS2 status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of Mycophenolic acid response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RIMS2 →	-1.426	-0.352	.018	.014	3	3
LARGE_INTESTINE	MYO15A →	+1.914	+0.390	.046	.016	3	3
BREAST	PCDHGA5 →	+2.684	+0.848	.035	.007	3	2
LUNG_NSCLC_LUAD	KEAP1 →	+1.933	+0.461	.012	.002	3	2
LUNG_SCLC	RYR2 →	-1.263	-0.562	.031	.001	3	2
BLOOD_Leukemia	DMXL2 →	+1.630	+0.395	.021	.006	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mycophenolic acid response by RIMS2 status — LUNG_NSCLC_LUAD

Explore this box plot interactively →