Mycophenolic acid

Across CCLE and GDSC cell-line panels, response to Mycophenolic acid is significantly associated with the protein-level pathway activity of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Mycophenolic acid response-associated pathways across cancer lineages are Negative regulation of proteasomal protein catabolic process, Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA catabolic process, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Mycophenolic acid response versus Negative regulation of proteasomal protein catabolic process protein-level pathway activity in LIVER (Pearson r = 0.81).

Protein-level pathway activity biomarkers of Mycophenolic acid response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of proteasomal protein catabolic process →	+0.368	+0.685	.007	.006	3	11
UPPER_AERODIGESTIVE_TRACT	Exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+1.281	+0.632	.023	.010	3	10
UPPER_AERODIGESTIVE_TRACT	rRNA catabolic process →	+1.286	+0.576	.010	.017	3	9
LARGE_INTESTINE	tRNA decay →	+1.224	+0.352	.007	.016	3	9
BREAST	Protein targeting to vacuole involved in autophagy →	-0.270	-0.952	<.001	<.001	3	9
OVARY	Negative regulation of ERAD pathway →	+1.067	+0.990	.006	.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mycophenolic acid response vs Negative regulation of proteasomal protein catabolic process — LIVER

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