Mitoxantrone

Across CCLE and GDSC cell-line panels, response to Mitoxantrone is significantly associated with the protein-level pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Mitoxantrone response-associated pathways across cancer lineages are Regulation of exocytosis, Cellular response to alcohol, and Phagosome maturation, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Mitoxantrone response versus Regulation of exocytosis protein-level pathway activity in PANCREAS (Pearson r = -0.42).

Protein-level pathway activity biomarkers of Mitoxantrone response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of exocytosis →	-0.150	-1.033	.019	.007	3	9
BONE	Cellular response to alcohol →	-0.233	-1.181	.001	.003	3	9
BONE	Phagosome maturation →	-0.171	-0.956	.026	.004	3	9
SKIN	Podosome assembly →	-0.834	-0.679	.008	.048	3	8
BONE	Phagocytosis, engulfment →	-0.178	-0.769	.045	.049	3	8
BONE	Regulation of ventricular cardiac muscle cell action potential →	-0.489	-0.849	.013	.011	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mitoxantrone response vs Regulation of exocytosis — PANCREAS

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