Mitomycin-C

Across CCLE and GDSC cell-line panels, response to Mitomycin-C is significantly associated with the pathway activity of multiple pathways, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible Mitomycin-C response-associated pathways across cancer lineages are IMP metabolic process, Heparan sulfate proteoglycan catabolic process, and Autophagosome maturation, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Mitomycin-C response versus IMP metabolic process pathway activity in KIDNEY (Pearson r = 0.51).

Pathway activity biomarkers of Mitomycin-C response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IMP metabolic process →	+0.168	+1.535	.026	.001	3	10
BONE	Heparan sulfate proteoglycan catabolic process →	-0.233	-2.137	<.001	.007	3	9
BREAST	Autophagosome maturation →	-0.071	-0.721	<.001	<.001	3	9
SOFT_TISSUE	Endosomal transport →	-0.042	-0.923	.010	.002	2	9
LIVER	Regulation of transforming growth factor beta1 production →	-0.244	-0.591	.001	.019	3	8
OVARY	Proteoglycan catabolic process →	-0.209	-0.863	.001	.003	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Mitomycin-C response vs IMP metabolic process — KIDNEY

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