Midostaurin

Across CCLE and GDSC cell-line panels, response to Midostaurin is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Midostaurin response-associated genes across cancer lineages are PCDH8, CREBBP, and DST, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Midostaurin response grouped by PCDH8 status in LARGE_INTESTINE.

Mutation status biomarkers of Midostaurin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCDH8 →	+3.000	+0.688	.017	<.001	3	3
BLOOD_Lymphoma	CREBBP →	+3.093	+0.326	.005	.004	3	2
OESOPHAGUS	DST →	+2.584	+0.323	.049	.041	3	2
BREAST	SZT2 →	+1.736	+0.427	.048	.034	3	2
LARGE_INTESTINE	YTHDC2 →	+2.807	+0.504	.027	.015	3	2
CNS	PKD1 →	+2.459	+0.405	.009	.010	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Midostaurin response by PCDH8 status — LARGE_INTESTINE

Explore this box plot interactively →