Midostaurin

Across CCLE and GDSC cell-line panels, response to Midostaurin is significantly associated with the protein-level pathway activity of multiple pathways, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible Midostaurin response-associated pathways across cancer lineages are Tissue migration, Nuclear transport, and Glucose catabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Midostaurin response versus Tissue migration protein-level pathway activity in OESOPHAGUS (Pearson r = 0.54).

Protein-level pathway activity biomarkers of Midostaurin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Tissue migration →	+1.058	+0.476	.005	.009	3	8
BREAST	Nuclear transport →	+0.174	+0.723	.003	.007	3	7
UPPER_AERODIGESTIVE_TRACT	Glucose catabolic process →	-0.347	-0.536	.001	.009	3	7
UPPER_AERODIGESTIVE_TRACT	Glycolytic process →	-0.304	-0.460	.002	.023	3	7
UPPER_AERODIGESTIVE_TRACT	Canonical glycolysis →	-0.347	-0.536	.001	.009	3	7
UPPER_AERODIGESTIVE_TRACT	Glucose catabolic process to pyruvate →	-0.347	-0.536	.001	.009	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Midostaurin response vs Tissue migration — OESOPHAGUS

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