MetAP2 Inhibitor

Across CCLE and GDSC cell-line panels, response to MetAP2 Inhibitor is significantly associated with the protein abundance of multiple proteins, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible MetAP2 Inhibitor response-associated proteins across cancer lineages are DNAJA1, HSP90AB1, and MORF4L1, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MetAP2 Inhibitor response versus DNAJA1 protein abundance in LARGE_INTESTINE (Pearson r = 0.41).

Protein abundance biomarkers of MetAP2 Inhibitor response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAJA1 →	+0.922	+0.482	.028	.003	3	9
OVARY	HSP90AB1 →	+1.151	+0.443	.026	.006	3	9
UPPER_AERODIGESTIVE_TRACT	MORF4L1 →	+0.832	+0.468	.002	.006	3	9
LARGE_INTESTINE	G3BP1 →	+0.957	+0.484	.005	.003	3	9
OVARY	RPS7 →	+0.868	+0.592	.002	<.001	3	9
LARGE_INTESTINE	CCT6B →	+1.590	+0.451	.004	.006	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MetAP2 Inhibitor response vs DNAJA1 — LARGE_INTESTINE

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