MPS-1-IN-1

Across CCLE and GDSC cell-line panels, response to MPS-1-IN-1 is significantly associated with the RNA expression of multiple genes, with BONE cell lines showing a particularly strong set of associations.

The most reproducible MPS-1-IN-1 response-associated genes across cancer lineages are HNRNPA1, ZNF724, and H3C6, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MPS-1-IN-1 response versus HNRNPA1 RNA expression in BONE (Pearson r = 0.72).

Rna expression biomarkers of MPS-1-IN-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HNRNPA1 →	+0.900	+1.498	<.001	.001	3	10
BONE	ZNF724 →	+1.622	+1.144	.002	.004	3	9
LARGE_INTESTINE	H3C6 →	-0.971	-0.693	.014	.023	3	9
STOMACH	RPL27A →	+0.935	+0.594	.028	.024	3	9
BONE	BAHCC1 →	+3.207	+1.394	.001	.001	3	8
BLOOD_Lymphoma	IFT20 →	-0.721	-0.636	.004	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPS-1-IN-1 response vs HNRNPA1 — BONE

Explore this scatter interactively →