MPS-1-IN-1

Across CCLE and GDSC cell-line panels, response to MPS-1-IN-1 is significantly associated with the protein abundance of multiple proteins, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible MPS-1-IN-1 response-associated proteins across cancer lineages are RPS25, RPA2, and ESYT2, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MPS-1-IN-1 response versus RPS25 protein abundance in KIDNEY (Pearson r = 0.54).

Protein abundance biomarkers of MPS-1-IN-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RPS25 →	+0.457	+0.524	.022	.014	3	9
LARGE_INTESTINE	RPA2 →	+0.963	+0.779	.001	.001	3	8
BONE	ESYT2 →	-1.013	-0.852	<.001	<.001	3	8
BONE	ARL6IP5 →	-1.450	-1.058	<.001	<.001	3	8
LUNG_NSCLC_LUSC	ERP44 →	+1.122	+0.970	.016	.021	3	7
BONE	DNAJB2 →	-1.578	-1.218	.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPS-1-IN-1 response vs RPS25 — KIDNEY

Explore this scatter interactively →