MN-64

Across CCLE and GDSC cell-line panels, response to MN-64 is significantly associated with the mutation status of multiple genes, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible MN-64 response-associated genes across cancer lineages are MUC16, DNAH5, and BIRC6, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, MN-64 response grouped by MUC16 status in KIDNEY.

Mutation status biomarkers of MN-64 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MUC16 →	-2.000	-0.387	.023	.019	3	4
LUNG_SCLC	DNAH5 →	-2.906	-0.322	.013	.029	3	3
UPPER_AERODIGESTIVE_TRACT	BIRC6 →	-2.921	-0.406	.018	.001	3	3
BLOOD_Lymphoma	CSMD3 →	-2.000	-0.285	.002	.011	3	2
LUNG_SCLC	XIRP2 →	-1.321	-0.315	.017	.010	3	2
LUNG_SCLC	PAPPA →	-2.736	-0.416	.027	.005	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MN-64 response by MUC16 status — KIDNEY

Explore this box plot interactively →