MN-64

Across CCLE and GDSC cell-line panels, response to MN-64 is significantly associated with the shRNA pathway dependency of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible MN-64 response-associated pathways across cancer lineages are Negative regulation of peptidyl-threonine phosphorylation, Positive regulation of amyloid fibril formation, and CD27 signaling pathway, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MN-64 response versus Negative regulation of peptidyl-threonine phosphorylation shRNA pathway dependency in STOMACH (Pearson r = 0.76).

Shrna pathway dependency biomarkers of MN-64 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of peptidyl-threonine phosphorylation →	+1.747	+0.703	<.001	.004	3	7
STOMACH	Positive regulation of amyloid fibril formation →	-0.393	-0.462	.001	.049	3	7
BONE	CD27 signaling pathway →	-2.445	-0.289	.013	.030	3	6
BLOOD_Leukemia	Melanosome assembly →	+1.464	+0.465	<.001	.006	3	6
LUNG_NSCLC_LUAD	Regulation of stem cell differentiation →	+0.143	+0.521	.024	.007	3	6
LARGE_INTESTINE	Negative regulation of centrosome duplication →	+0.196	+0.285	.005	.042	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MN-64 response vs Negative regulation of peptidyl-threonine phosphorylation — STOMACH

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