MK-1775

Across CCLE and GDSC cell-line panels, response to MK-1775 is significantly associated with the total protein of multiple proteins, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible MK-1775 response-associated proteins across cancer lineages are Acetyl-a-Tubulin-Lys40, SF2, and PARP_cleaved, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MK-1775 response versus Acetyl-a-Tubulin-Lys40 total protein in BREAST (Pearson r = 0.45).

Total protein biomarkers of MK-1775 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Acetyl-a-Tubulin-Lys40 →	+0.502	+0.567	.008	.005	3	7
SKIN	SF2 →	+0.287	+0.430	.017	.031	2	7
SOFT_TISSUE	PARP_cleaved →	+0.594	+0.640	.017	.018	3	6
CNS	PEA-15 →	-0.340	-0.800	.001	.001	3	6
LUNG_NSCLC_LUSC	MSH2 →	+0.787	+0.987	.039	.015	2	6
LUNG_NSCLC_LUSC	Chk2_pT68 →	+0.754	+1.126	.030	.030	1	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MK-1775 response vs Acetyl-a-Tubulin-Lys40 — BREAST

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