MIRA-1

Across CCLE and GDSC cell-line panels, response to MIRA-1 is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible MIRA-1 response-associated genes across cancer lineages are ADGRV1, AHNAK, and ADGRG4, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, MIRA-1 response grouped by ADGRV1 status in LUNG_NSCLC_LUSC.

Mutation status biomarkers of MIRA-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ADGRV1 →	+2.321	+0.257	.047	.032	3	3
OESOPHAGUS	AHNAK →	+2.247	+0.372	.021	.002	3	3
LARGE_INTESTINE	ADGRG4 →	+2.169	+0.286	.020	.038	3	3
LARGE_INTESTINE	CACNA1H →	+3.000	+0.322	.014	.020	3	3
BLOOD_Myeloma	TP53 →	-2.000	-0.519	.047	.015	3	2
LUNG_NSCLC_LUAD	BCLAF1 →	+3.000	+0.297	.025	.032	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIRA-1 response by ADGRV1 status — LUNG_NSCLC_LUSC

Explore this box plot interactively →