MIRA-1

Across CCLE and GDSC cell-line panels, response to MIRA-1 is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible MIRA-1 response-associated pathways across cancer lineages are Regulation of protein localization to cell periphery, Positive regulation of ion transmembrane transporter activity, and Clathrin-dependent endocytosis, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MIRA-1 response versus Regulation of protein localization to cell periphery protein-level pathway activity in BONE (Pearson r = -0.61).

Protein-level pathway activity biomarkers of MIRA-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of protein localization to cell periphery →	-0.282	-0.469	<.001	<.001	3	10
OVARY	Positive regulation of ion transmembrane transporter activity →	-0.281	-0.554	.002	.003	3	10
BONE	Clathrin-dependent endocytosis →	-0.289	-0.441	<.001	.004	3	10
BONE	Regulation of protein localization to plasma membrane →	-0.209	-0.444	<.001	<.001	3	9
LARGE_INTESTINE	Epithelial cell development →	-0.287	-0.545	.001	.001	3	9
LUNG_SCLC	Regulation of exocytosis →	-0.159	-0.526	.018	.002	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIRA-1 response vs Regulation of protein localization to cell periphery — BONE

Explore this scatter interactively →