MIM1

Across CCLE and GDSC cell-line panels, response to MIM1 is significantly associated with the pathway activity of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible MIM1 response-associated pathways across cancer lineages are Positive regulation of sodium ion transmembrane transport, Serotonin uptake, and Ribosome biogenesis, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, MIM1 response versus Positive regulation of sodium ion transmembrane transport pathway activity in SOFT_TISSUE (Pearson r = -0.71).

Pathway activity biomarkers of MIM1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of sodium ion transmembrane transport →	-0.354	-0.932	<.001	<.001	3	8
SOFT_TISSUE	Serotonin uptake →	+1.339	+0.864	.030	.008	3	8
OVARY	Ribosome biogenesis →	+0.112	+0.746	.005	.003	3	8
STOMACH	rRNA transcription →	+0.143	+0.600	.012	.038	2	9
URINARY_TRACT	AMP metabolic process →	+0.164	+0.502	.009	.038	3	8
URINARY_TRACT	Spermidine biosynthetic process →	+0.075	+0.474	.038	.009	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIM1 response vs Positive regulation of sodium ion transmembrane transport — SOFT_TISSUE

Explore this scatter interactively →